从氨基和生物衍生型甲替代物中氧化合成甲胺的氧化合成

Xingchao Dai1, Yunyan Han1,2, Haijun Jiao1

  • 1Leibniz-Institut für Katalyse e.V. an der, Universität Rostock (LIKAT), Albert-Einstein-Str. 29a, 18059, Rostock, Germany.

概括

这项研究介绍了一种高效的方法,用于合成使用铜催化剂和氧气的formamides. 这种新的方法利用生物衍生形式来源,与贵金属催化剂相比,它表现出更高的活性.

相关概念视频

Preparation of 1° Amines: Gabriel Synthesis01:28

Preparation of 1° Amines: Gabriel Synthesis

Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
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In the presence of an aqueous base and a halogen, primary amides can lose the carbonyl (as carbon dioxide) and undergo rearrangement to form primary amines. This reaction, called the Hofmann rearrangement, can produce primary amines (aryl and alkyl) in high yields without contamination by secondary and tertiary amines.
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Preparation of 1° Amines: Azide Synthesis01:22

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