相关实验视频
Updated: Jun 29, 2025

Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
疾病感知作为症状集群轨迹的预测者在炎症性肠病患者中:潜增长混合模型
Shen Zhijia1,2,3,4,5,6,7,8,9, Xi Meijuan1,2,3,4,5,6,7,8,9, Zhou Yanting1,2,3,4,5,6,7,8,9
1Shen Zhijia, MSN, RN, is a Registered Nurse, Gastroenterology Department, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, SuZhou, China.
在infliximab治疗中患有炎症性肠病的患者随着时间的推移表现出明显的症状模式. 疾病的感知影响了这些症状轨迹,突出了对量身定制的患者支持的需要.
科学领域:
- 胃肠病学 胃肠病学
- 精神病体医学是一种精神病体医学.
- 临床研究 临床研究
背景情况:
- 炎症性肠病 (IBD) 管理包括生物疗法,如infliximab.
- 了解症状进展和患者的看法对于优化治疗结果至关重要.
- 在接受因弗力西马布治疗的IBD患者中,症状集群及其轨迹需要进一步调查.
研究的目的:
- 在第一个28周治疗因弗利克西马布治疗期间,确定IBD患者的症状集群轨迹.
- 探索疾病感知与这些已识别的症状集群轨迹之间的联系.
主要方法:
- 一项前性队列研究,涉及206名IBD患者开始使用infliximab.
- 在基线,14周和28周使用经过验证的尺度评估的症状集群.
- 用于数据分析的潜增长混合模型和简短的疾病感知问卷.
主要成果:
- 确定了三个不同的症状集群轨迹:中度稳定下降 (C1),高快速下降 (C2) 和稳定趋势 (C3).
- 认知疾病的感知预测了中等稳定下降 (C1) 轨迹.
- 认知和情绪疾病的感知预测了高速下降 (C2) 轨迹.
结论:
- 开始使用因弗利克西马布的IBD患者表现出不同的症状集群轨迹.
- 疾病的感知与特定的症状集群模式显著相关.
- 将心理支持和患者教育与因弗力西马布治疗相结合,可能会减轻症状负担.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Assessment of the Gastrointestinal System II: Health Perception Pattern
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

