杆菌感染与与代谢功能障碍相关的脂肪性肝病风险之间的关系:更新的元分析
Alessandro Mantovani1, Maria Giovanna Lando1, Nicolò Borella1
1Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
概括
杆菌感染与发展代谢功能障碍相关的脂肪性肝病 (MASLD) 风险的轻微增加有关. 这一元分析证实了流行和偶发的MASLD病例之间的小关联.
科学领域:
- 胃肠病学和肝病学
- 传染性疾病 传染性疾病
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 关于Helicobacter pylori (H. pylori) 感染与代谢功能障碍相关的脂肪性肝病 (MASLD) 之间的关联,存在相互矛盾的观察数据.
- 杆菌是一种常见的细菌感染,具有潜在的全身影响.
- MASLD是一个与代谢综合征相关的日益严重的全球健康问题.
研究的目的:
- 进行一项元分析,量化H. pylori感染与MASLD风险之间的关联.
- 解决先前的观察研究中相互矛盾的发现.
- 提供H. pylori感染在MASLD发展中所带来的风险的可靠估计.
主要方法:
- 系统地搜索三个主要的电子数据库,查找符合条件的观测研究,直到2023年11月.
- 包括使用肝脏活检,成像或生物标志物用于MASLD诊断的研究.
- 使用随机效应建模进行的元分析,对异质性,子组,元回归和出版偏差进行评估.
主要成果:
- 分析了28项研究 (231,291人,主要是亚洲人).
- H. pylori 感染与患有流行性 MASLD 的风险增加显著相关 (OR 1.11,95% CI 1.05-1.18).
- 在5年的随访期间,H. pylori感染与发生MASLD的风险增加显著相关 (OR 1.20,95% CI 1.08-1.33).
结论:
- H. pylori 感染与流行和发病MASLD的风险略有增加有关.
- 这些发现表明,H. pylori在MASLD病变发生过程中可能发挥作用.
- 需要进一步的前性和机制性研究来阐明复杂的关系.
相关概念视频
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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
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