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使用综合生物信息学分析识别HIST1H2BH作为与多发性骨髓瘤相关的枢纽基因

Wenxue Zhang1, Xian Chen1, Zhe Wang1

  • 1Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.

Hematology (Amsterdam, Netherlands)
|April 3, 2024
PubMed
概括

在多发性骨髓瘤 (MM) 患者中增加HIST1H2BH表达与预后较差相关. 这一发现表明HIST1H2BH是MM进展和向治疗开发的潜在生物标志物.

关键词:
H2B 蛋白质家族的 H2B 蛋白质家族.多发性骨髓瘤是一种多发性骨髓瘤.生物信息学分析分析不同表达基因的基因.表观遗传调节 表观遗传调节基斯顿基因基因基因基因基因基因基因基因基因基因基因基因基因基因核心基因 核心基因 核心基因独立的预后因素 独立的预后因素

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Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
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