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在多发性硬化症中,进展的决定因素和生物标志物独立于复发

Massimiliano Calabrese¹, Paolo Preziosa^2,3,4, Antonio Scalfari⁵

¹Department of Neurosciences and Biomedicine and Movement, The Multiple Sclerosis Center of University Hospital of Verona, Verona, Italy.

Annals of neurology

|April 3, 2024

概括

多发性硬化症 (MS) 中燃烧着的炎症导致逐渐残疾,独立于复发. 了解这些早期的,病变独立的机制是开发慢性恶化的新疗法的关键.

科学领域:

神经学神经学
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

多发性硬化症 (MS) 从早期就表现出燃烧着的炎症活动,导致残疾的持续进展.
这种慢性恶化,称为不依赖复发活动 (PIRA) 的进展,与急性复发和新病变形成不同.
关键的病理事件包括分离的中枢神经系统 (CNS) 炎症,修复功能受损和线粒体功能障碍.

研究的目的:

审查当前的神经病理学,免疫学和成像学研究结果,以了解MS中燃烧疾病活动的机制.
探索潜在的早期生物标志物,用于燃烧的MS.
讨论这些生物标志物的转化到临床实践中.

主要方法:

对MS的临床,病理和成像研究的综合文献综述.
对慢性残疾进展背后的机制的分析.
专注于病变独立的病理过程.

主要成果:

燃烧着的炎症有助于神经轴损伤,髓损失和质细胞的改变.
机制包括中枢神经系统局部的炎症,不足的修复和线粒体衰竭.
这些过程导致神经元网络功能障碍,超过中枢神经系统的补偿能力.

结论:

燃烧性疾病活动是MS患者不可逆转残疾的关键驱动因素.
确定这个过程的早期生物标志物对于有效的治疗策略至关重要.
将正在燃烧的MS研究转化为临床实践对于改善患者的治疗结果至关重要.

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