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泰国东北部人口中12个X染色体STR位点的法医效率和遗传多态性

Suparat Srithawong¹, Kanha Muisuk², Nonglak Prakhun¹

¹Department of Biology, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.

Molecular genetics and genomics : MGG

|April 3, 2024

概括

这项研究分析了泰国东北部的12个X短串联重复 (STR),揭示了法医应用的高分辨能力. 这些发现为老人群建立了关键的X-STR频率数据,并有助于区分泰国地区群体.

科学领域:

法医遗传学法医遗传学
人口遗传学人口遗传学
人类学是人类学.

背景情况:

泰国先前的法医短串重复 (STR) 研究主要集中在自体性STR上,对X-STR的数据有限,特别是在东北地区.
泰国东北部的民族多样化,老人占多数,还有九个不同的少数群体.

研究的目的:

为泰国东北部建立12个X-STR位置的参考数据库.
评估X-STRs在该地区的法医有效性.
调查人口遗传学和泰国东北部各族群之间的遗传差异化.

主要方法:

在泰国东北部的十个种群中,使用12个X-STR位点对896个个体进行基因定型.
对等位基频率,联合歧视力 (CPD) 和联合平均排除机会 (MEC) 的统计分析.
使用X-STR数据与其他泰国人群进行遗传比较.

主要成果:

在所有十个人口中观察到高的联合歧视力和联合平均排斥机会 (MEC > 0.99999).
DXS10148是最有信息的标记,而DXS7423是最没有信息的标记.
X-STR频率支持某些少数群体 (Kuy,Saek,Nyahkur) 的遗传区别,并突出了泰国内部的区域遗传差异.

结论:

12个X-STR位点对泰国东北部的法医应用和人类遗传学具有高度信息意义.
这项研究填补了老人口X-STR参考数据中的关键缺口,有利于泰国和邻国的法医案例工作.
已建立的X-STR概况有助于了解泰国多样化人口的遗传景观.

关键词:

基的频率基的频率法医微卫星法医微卫星泰国的东北地区.它们是X-STR.在X染色体的微卫星中.

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