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In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
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The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
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Quantification of Cell-Substrate Adhesion Area and Cell Shape Distributions in MCF7 Cell Monolayers
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模拟非局部细胞-细胞粘附:一种多尺度的方法.

Anna Zhigun1, Mabel Lizzy Rajendran2

  • 1School of Mathematics and Physics, Queen's University Belfast, University Road, Belfast, BT7 1NN, Northern Ireland, UK. A.Zhigun@qub.ac.uk.

Journal of mathematical biology
|April 3, 2024
PubMed
概括

本研究引入了细胞迁移的多尺度模型,结合了确定性粘附和随机运动. 该模型捕捉了细胞粘附如何影响生物系统中的种群动态和运动模式.

关键词:
卡德林结合 卡德林结合细胞粘附分子结合的细胞粘附分子.细胞运动 细胞运动细胞对细胞的粘附.扩散-附着方程的扩散-附着方程.过度波动缩放的缩放.动力运输方程的动力运输方程多尺度建模的多尺度建模近视扩散的近视扩散非本地模型非本地模型抛物线缩放的缩放方式

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科学领域:

  • 数学生物学 数学生物学
  • 生物物理学的生物物理.
  • 计算生物学 计算生物学

背景情况:

  • 细胞-细胞粘附对于多细胞生物的发展和维护至关重要.
  • 它调节细胞迁移,对于胚胎生成和癌症进展等过程至关重要.

研究的目的:

  • 为自粘性细胞种群开发一种多功能多尺度建模方法.
  • 为了将微观的粘附机制与中视尺度的随机过程相结合.

主要方法:

  • 一种多尺度的方法,结合了确定性的微观粘附与随机的介面镜速度跳跃过程.
  • 导出具有多个非局部性的中镜动力运输方程.
  • 应用抛物线和高抛物线缩放以获得宏观模型.

主要成果:

  • 该模型产生了具有非局部粘附和近视扩散的动力运输方程.
  • 模拟显示了粘附和随机运动对细胞群动态的联合影响.
  • 一个新的非线性积分方程与细胞密度方程相结合,可以在宏观尺度上捕捉微观粘附效应.

结论:

  • 开发的多尺度方法为模拟受粘附影响的细胞迁移提供了强大的框架.
  • 该模型有效地将亚细胞粘附分子与宏观人口行为结合起来.
  • 这项工作提供了关于细胞群体在生物环境中的复杂动态的见解.