在SPIROMICS参与者患有慢性阻塞性肺部疾病的空气污染暴露和间歇性肺部特征
Nicolas A Baddour1, Laura M Paulin2, Amanda J Gassett3
1Department of Medicine.
Annals of the American Thoracic Society
|April 3, 2024
概括
空气污染与慢性阻塞性肺病 (COPD) 患者的间歇性肺异常无关. 然而,MUC5B基因和吸烟状态改变了空气污染物和间歇性肺异常风险之间的关联.
科学领域:
- 环境健康 环境健康
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
背景情况:
- 慢性阻塞性肺病 (COPD) 患者的空气污染和间歇性肺病 (ILD) 特征之间的关系尚不清楚.
- 研究空气污染对放射性发现的影响,如COPD的间歇性肺异常 (ILA) 和高衰减区域 (HAA) 是至关重要的.
研究的目的:
- 为了确定暴露于环境空气污染是否会增加ILA或HAA的患病率,计算机断层扫描 (CT) 扫描在患有COPD和严重吸烟史的人群中.
- 探索由MUC5B促进体多态性,吸烟状态,性别和肺气百分比对空气污染和间歇性肺部特征之间的关联的潜在效果修饰.
主要方法:
- 一项采用SPIROMICS队列数据的横截面研究,重点关注患有COPD的现有或前吸烟者.
- 基于住所地址的经过验证的时空模型,估计10年暴露在PM2.5,NOx,NO2和臭氧中的情况.
- 采用多变量回归模型来评估污染暴露与ILA/HAA之间的关联,并对效果修饰剂进行相互作用分析.
主要成果:
- 在整体COPD队列中,一般空气污染暴露与ILA或HAA的流行率之间没有发现显著的关联.
- 空气污染物暴露与ILA风险之间的关联因MUC5B促进体多态性和吸烟状况而显著改变.
- 具体来说,MUC5B变异携带者表现出更高NOx和PM2.5暴露的ILA风险增加,而前吸烟者表现出更高NO2暴露的ILA风险增加.
结论:
- 环境空气污染暴露在COPD重度吸烟者队列中的CT扫描中与间歇性肺部特征没有直接关联.
- 基因与环境的相互作用,特别是涉及MUC5B多态和吸烟史,在调节COPD中空气污染和间歇性肺异常之间的关系方面发挥着重要作用.
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