乙氨基会影响肌肉骨信号传递,但不会影响耐力运动训练的适应性
Brandon M Roberts1, Alyssa V Geddis1, Alexandra Ciuciu2
1Military Performance Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.
概括
低剂量的乙氨基 (ACE) 并没有影响运动大鼠的慢性肌肉和骨适应. 然而,ACE在运动后急剧降低了AMPK酸化和4EBP1脱酸化,这表明可能会干扰运动信号.
科学领域:
- 运动生理学 运动生理学
- 药理学 药理学是指药理学的学科.
- 生物医学科学 生物医学科学
背景情况:
- 乙氨基 (ACE) 是一种常见的止痛药和抗炎药.
- 以前对ACE对运动,肌肉和骨健康的影响的研究已经产生了不一致的结果.
- 了解ACE对肌肉骨适应的影响对运动员和一般健康至关重要.
研究的目的:
- 为了研究6周低剂量乙氨基 (ACE) 治疗对运动和不运动的老鼠肌肉和骨适应的影响.
- 确定ACE是否影响与肌肉生长和骨代谢相关的关键信号通路.
- 探索ACE对肌肉细胞的潜在超生理效应.
主要方法:
- 一项为期6周的研究涉及Wistar大鼠,随机分为运动/控制和ACE/安慰剂组.
- 老鼠接受了标准化的跑步机炼方案,每周5天.
- 肌肉 (CSA,纤维类型,信号) 和骨 (股骨生物力学,微CT) 的参数被评估,并进行细胞培养实验.
主要成果:
- ACE没有影响体重,食物/水摄入量或跑步机的表现.
- 运动增加了AMPK酸化,而AMPK酸化被ACE减弱.
- 与安慰剂相比,ACE治疗在运动和对照组中增加了-4EBP1水平.
结论:
- 低剂量的ACE并没有改变运动动物的慢性肌肉骨适应.
- ACE急性减弱了运动诱导的AMPK酸化和4EBP1脱酸化.
- 这些发现表明,ACE可能会干扰与运动相关的分子信号通路.
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