毒素菌感染和丸激素改变:一个系统的审查和元分析
Amir Abdoli1,2, Fatemeh Ghaffarifar3, Zohreh Sharifi4
1Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran.
PloS one
|April 3, 2024
概括
毒素斑块淋巴体 (T. gondii) 感染与男性和女性的丸激素水平变化有关. 这项系统性审查发现感染人类的丸激素增加,但在动物身上得到了混合的结果,突出了进一步研究的必要性.
科学领域:
- 寄生虫学的寄生虫学
- 内分泌学 在内分泌学.
- 行为科学 行为科学
背景情况:
- 毒淋巴菌 (T. gondii) 是一种广泛传播的原生虫寄生虫,感染人类和动物.
- 潜伏性毒性质炎可以改变性激素,特别是丸激素,这会影响行为和生殖.
研究的目的:
- 系统地审查和总结有关T. gondii感染与人类和动物丸激素变化的相关证据.
主要方法:
- 使用主要科学数据库 (PubMed,Scopus,Web of Science等) 进行了系统审查. 在2023年1月之前.
- 遵循PRISMA指南,选了超过12,000篇文章,其中24篇符合纳入标准.
- 用元分析 (随机效应模型) 来结合的差异,埃格尔的回归评估了出版偏差.
主要成果:
- 分析了24种物品 (18种人类,6种动物).
- 大多数人类研究表明,T. gondii感染的男性丸激素增加;综合分析显示,男性丸激素增加了0.73个单位,女性丸激素增加了0.55个单位.
- 动物研究显示了混合的结果,一些报告降低了丸激素,而另一些则增加了水平.
结论:
- 淋巴球菌感染与人类和动物的丸激素变化有关.
- 增加的丸激素可能与增强的性行为和寄生虫传播有关.
- 降低丸激素可能表明男性生殖能力受损,需要进一步调查.
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