绝经时的年龄,血管风险和加拿大老龄化长度研究中的3年认知变化之间的关联
Madeline Wood Alexander1, Che-Yuan Wu1, Gillian T Coughlan1
1From the Hurvitz Brain Sciences Program (M.W.A., C.-Y.W., W.S., M.M., S.E.B., J.S.R.), Sunnybrook Research Institute; Rehabilitation Sciences Institute (M.W.A., J.S.R.), Department of Pharmacology & Toxicology (C.-Y.W., W.S.), University of Toronto, Ontario, Canada; Department of Neurology (G.T.C., R.F.B.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Psychology (T.P.), University of British Columbia, Vancouver, Canada; Center for Alzheimer Research and Treatment (CART) (R.F.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Melbourne School of Psychological Sciences (R.F.B.), University of Melbourne, Parkville, Victoria, Australia; Department of Neurology (P.P.), University of North Carolina at Chapel Hill School of Medicine; Division of Neurology (M.M., S.E.B., J.S.R.), Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto; Campbell Family Mental Health Research Institute (L.A.M.G.), The Centre for Addition and Mental Health; Department of Psychiatry (L.A.M.G.), Temerty Faculty of Medicine, Dalla Lana School of Public Health (G.E.), and Department of Psychology (G.E.), University of Toronto; Rotman Research Institute (G.E.), Baycrest Hospital; and Harquail Centre for Neuromodulation (J.S.R.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada.
早期更年期与血管风险因素相结合,协同增加了女性认知能力下降的风险. 激素治疗没有改变这种关联,突出了需要性别特异性痴呆症预防策略的需要.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 内分泌学 在内分泌学.
背景情况:
- 阿尔茨海默病 (AD) 风险显示性别差异,可能受到女性血管和荷尔蒙因素的影响.
- 研究更年期年龄,血管风险和激素治疗 (HT) 的相互作用对于了解更年期后妇女的认知健康至关重要.
研究的目的:
- 检查更年期的年龄,血管风险和HT史如何相互作用,影响三年内认知功能.
- 测试早期更年期和较高的血管风险协同影响认知,HT可能减轻这种影响的假设.
主要方法:
- 利用了加拿大长度老龄化研究的数据,比较了8,360名绝经后妇女和年龄相匹配的男性.
- 计算了血管风险得分 (高血压,药物,胆固醇,糖尿病,吸烟,肥胖) 并评估了基线和3年随访的全球认知.
- 采用线性模型分析更年期年龄,血管风险和HT对认知的独立和相互作用影响,控制共变量.
主要成果:
- 更年期年龄和血管风险之间的相互作用表明,更早的更年期和更高的血管风险与较低的认知分数 (p=0.03) 有协同作用.
- 这种协同效应在更年期早期的女性 (35-48岁) 中显著,血管风险对认知产生负面影响比男性更强.
- 激素治疗史没有改变更年期年龄和认知结果的血管风险之间的协同关联 (p=0.69).
结论:
- 血管和内分泌因素似乎在协同作用,增加女性认知能力下降的风险.
- 研究结果表明,需要在痴呆症预防策略中采取性别特定的方法,重点关注早期更年期妇女的血管风险管理.
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