心力衰竭监测方面的进展:生物传感器针对外围生物流体中的分子标记物
Tao Dong1, Wangang Zhu2, Zhaochu Yang3
1Chongqing Key Laboratory of Micro-Nano Systems and Intelligent Transduction, Collaborative Innovation Center on Micro-Nano Transduction and Intelligent Eco-Internet of Things, Chongqing Key Laboratory of Colleges and Universities on Micro-Nano Systems Technology and Smart Transducing, National Research Base of Intelligent Manufacturing Service, School of Mechanical Engincering, Chongqing Technology and Business University, Nan'an District, Chongqing, 400067, China; X Multidisciplinary Research Institute, Faculty of Instrumentation Science and Technology, State Key Laboratory for Manufacturing Systems Engineering, International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies, Xi'an Jiaotong University, Xi'an, 710049, China; Department of Microsystems- IMS, Faculty of Technology, Natural Sciences and Maritime Sciences, University of South-Eastern Norway-USN, P.O. Box 235, Kongsberg, 3603, Norway.
本综述强调了用于心力衰竭诊断和预后的关键生物标志物,包括性尿素和心脏特罗波宁. 电化学生物传感器显示出对这些关键心力衰竭标志物的敏感检测有前途.
科学领域:
- 生物医学工程 生物医学工程
- 心脏病学 心脏病学
- 生物标志物发现发现
背景情况:
- 心血管疾病,特别是心力衰竭,对全球健康构成重大挑战.
- 由于心力衰竭的复杂性,准确的查,诊断和预后至关重要.
- 生物标志物和生物传感器技术提供了快速而精确的诊断能力.
研究的目的:
- 为提供心力衰竭分子生物标志物的最新概述.
- 审查用于检测心力衰竭生物标志物的最新生物传感器技术.
- 巩固心力衰竭领域的研究人员和患者的科学信息.
主要方法:
- 对有关心力衰竭生物标志物的当前文献进行系统审查.
- 对六种主要心力衰竭病因路径中已建立和新兴生物标志物的分析.
- 评估用于生物标志物检测的电化学生物传感器性能.
主要成果:
- 已经确立的黄金标准生物标志物包括血性尿素 (BNP,NT-proBNP) 和心脏性热素 (cTnT,cTnI).
- 还讨论了其他补充生物标志物,如GDF-15,Gal-3,sST2,CRP和TNF-α.
- 电化学生物传感器对这些生物标志物具有高灵敏度,特异性和低检测极限.
结论:
- 该评论系统地总结了心力衰竭的尖端分子生物标志物和生物传感器.
- 这些信息对生物医学和电子传感研究人员至关重要.
- 未来的前景可能会激发心力衰竭诊断的新研究方向.
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