在新生儿重症监护病房的新生儿重症监护病人的持续暴露于内分泌干扰甲酸盐和替代性可塑剂
Lucas Panneel1, Paulien Cleys2, Giulia Poma2
1Neonatal Intensive Care Unit, Antwerp University Hospital, Edegem, Belgium; Laboratory for Experimental Medicine and Paediatrics, University of Antwerp, Wilrijk, Belgium.
Environment international
|April 3, 2024
概括
在新生儿重症监护室 (NICU) 的早产婴儿显示高甲酸盐暴露,超过安全水平,尽管有规定. 越来越多地检测到替代性增塑剂,对脆弱的新生儿构成未知的风险.
科学领域:
- 环境健康 环境健康
- 新生儿毒理学 新生儿毒理学
- 内分泌学 在内分泌学.
背景情况:
- 由于对内分泌系统的干扰,二甲基甲酸盐 (DEHP) 是一种增塑剂,在医疗器械中受到限制.
- 替代性增塑剂正在取代DEHP,但它们的安全概况尚未完全理解.
- 新生儿,特别是新生儿重症监护室 (NICU) 的新生儿,特别容易受到塑化剂毒性的影响.
研究的目的:
- 评估住院的早产新生儿对甲酸盐和替代性增塑剂的暴露.
- 为了比较早产新生儿和临床对照之间的暴露水平.
- 评估NICU干预对塑化剂暴露的影响.
主要方法:
- 在2020年6月至2022年8月期间,从132名早产新生儿和21名术后对照人群收集了尿液样本.
- 液体染色学与双重质谱学相结合,用于分析甲酸盐和替代性可塑化剂代谢物.
- 暴露水平在各组之间进行了比较,并与NICU干预相关联.
主要成果:
- 在几乎所有尿样中检测到甲酸代谢物.
- 经常检测到 (30-95%) 的替代性增塑剂代谢物 (DEHA,DEHT,DINCH).
- 过早出生的新生儿的甲基度明显高于对照组,其水平在产后增加,并与呼吸支和血液产品暴露相关.
结论:
- 尽管有欧盟法规,NICU中的早产新生儿仍然暴露在高于安全水平的酸盐中.
- 对替代性塑化剂的暴露在NICU中正在增加,需要进一步进行毒理学评估.
- 目前的法规没有充分解决针对脆弱婴儿群体的医疗器械中替代性增塑剂的风险.
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