通过调节免疫微环境和PI3K/AKT/mTOR通路,PSMC2促进质瘤的进展
Yizheng Wang1, Shiyang Zhang2, Zijun Zhao3
1Pain Rehabilitation, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Immunobiology
|April 3, 2024
概括
蛋白质酶26S亚单元ATPase 2 (PSMC2) 在质瘤中升高,使患者的生存率恶化. 抑制PSMC2抑制瘤生长并影响瘤微环境,为脑癌提供潜在的新治疗标.
科学领域:
- 神经瘤学神经瘤学
- 癌症生物学 癌症生物学
- 免疫学 免疫学 免疫学
背景情况:
- 质瘤是一种常见的恶性脑癌,结果不佳.
- 蛋白酶26S亚基ATPase2 (PSMC2) 参与瘤发育,但其在质瘤中的作用尚不清楚.
研究的目的:
- 研究PSMC2在质瘤中的表达,预后意义和功能作用.
- 探索PSMC2与瘤免疫微环境之间的关系,包括DNA甲基化,免疫细胞透和免疫检查点.
- 为了阐明涉及PSMC2介导的质瘤进展的潜在分子途径.
主要方法:
- 在质瘤组织中分析PSMC2表达和与患者存活率的相关性.
- 检查PSMC2与免疫特征 (甲基化,透,循环,平衡,检查点) 的关联.
- 在体外实验 (包括免疫组织化学) 以验证PSMC2功能,增殖,细胞循环和细胞亡,以及途径分析 (GSEA,GSVA).
主要成果:
- 与正常组织相比,PSMC2表达在质瘤组织中显著上调.
- 高PSMC2表达与质瘤患者的整体存活率差相关.
- PSMC2与免疫抑制细胞和免疫检查点积极关联,同时对癌症免疫循环和平衡产生负面影响.
- 抑制PSMC2可降低质瘤细胞的攻击性和增殖,诱导细胞循环停止和亡.
- 通过PI3K/AKT/mTOR信号通路,PSMC2促进结质瘤的发生.
结论:
- 在质瘤中,PSMC2是上调调节的,并驱动癌症的进展.
- PSMC2 影响瘤免疫微环境和癌细胞行为.
- 向PSMC2为质瘤治疗提供了一个潜在的治疗策略.
相关概念视频
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
01:22PI3K/mTOR/AKT Signaling Pathway
3.5K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.5K
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
01:19Interactions Between Signaling Pathways
6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K