可溶性因子CD14,CD163和迁移抑制因子与子宫内膜异位症相关的不孕症有关
Nanda Yuli Rahmawati1, Fadhil Ahsan2, Budi Santoso2
1Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Gynecologic and obstetric investigation
|April 3, 2024
概括
溶性CD163 (sCD163) 和巨细胞迁移抑制因子 (MIF) 的血清水平升高与子宫内膜异位症的严重程度相关. 这些标记物显示出作为诊断子宫内膜异位症相关不孕症的非侵入性生物标记物的潜力.
科学领域:
- 生殖免疫学 生殖免疫学
- 妇科病理学的病理学.
- 发现生物标志物的发现.
背景情况:
- 髓状细胞影响子宫内膜异位症免疫病理学.
- 可溶性CD14 (sCD14),CD163 (sCD163) 和巨细胞迁移抑制因子 (MIF) 是髓状细胞功能的标记物.
- 这些标志物在与子宫内膜异位症相关的不孕症中未得到充分研究.
研究的目的:
- 为了研究与子宫内膜异位症相关的不孕症妇女的sCD14,sCD163和MIF的血清和腹液水平.
- 为了将这些标志物水平与子宫内膜异位症的阶段和严重程度相关联.
- 评估这些标记物在区分子宫内膜异位症的诊断潜力.
主要方法:
- 有望招募87名女性进行诊断性腹腔镜以治疗不孕症.
- 对44名子宫内膜异位症患者 (19名早期,25名晚期) 和43名对照患者的分析.
- 使用ELISA在血清和腹液中的sCD14,sCD163和MIF的量化.
主要成果:
- 子宫内膜异位症患者的血清sCD163和MIF水平明显高于对照组.
- 无论是sCD163和MIF水平,都与美国生殖医学协会 (rASRM) 修订的粘附得分具有积极的相关性.
- 此外,MIF水平与整体rASRM子宫内膜异位症得分呈正相关.
- 血清sCD163和MIF在子宫内膜异位症和非子宫内膜异位症病例之间表现出显著的区分能力.
结论:
- 系统性sCD163和MIF水平的升高与子宫内膜异位症的严重程度有关.
- 这些可溶性分子显示为子宫内膜异位症的非侵入性生物标志物具有前途.
- 需要进一步的研究来阐明sCD163和MIF在子宫内膜异位症相关不孕症中的作用.
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