修改聚多巴胺介导的金属有机框架,以提高生物相容性
Jiayu Feng1, Liwang Xu1, Lulu Qi1
1College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310032, China.
Macromolecular bioscience
|April 3, 2024
概括
聚多巴胺涂层显著降低了细胞中氧化伊米达酸框架-8 (ZIF-8) 纳米材料的毒性. 这种生物相容的修改增强了金属有机框架 (MOF) 对于安全的纳米医学和药物输送应用的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 纳米医学是一种纳米医学.
- 细胞毒理学细胞毒理学
背景情况:
- 工程纳米材料提供了重要的生物医学潜力,但由于生物相容性数据不足而面临挑战.
- 金属有机框架 (MOFs),特别是热性伊米达酸框架-8 (ZIF-8),正在成为纳米医学中的关键参与者.
- 了解和减轻纳米材料的细胞毒性对于其临床转化至关重要.
研究的目的:
- 研究聚多巴胺 (PDA) 涂层对ZIF-8纳米材料生物相容性的影响.
- 阐明ZIF-8诱导的细胞毒性背后的机制.
- 评估PDA修改ZIF-8在安全的纳米药物输送系统中的潜力.
主要方法:
- 在体外细胞毒性测定使用RAW264.7,LO2和HST6细胞系.
- 评估反应性氧物种 (ROS) 生成,细胞循环和自.
- 在体内测试使用人类脉内皮细胞和斑马鱼胚胎.
主要成果:
- PDA涂层显著减轻了ZIF-8在多种细胞类型中的细胞毒性.
- 通过增加ROS生成,ZIF-8诱导了细胞毒性,导致细胞周期延迟和自.
- 在体外和体外模型中,PDA修改有效地减轻了ZIF-8的毒性.
结论:
- 聚多巴胺涂层是一种可行的策略,可以提高ZIF-8纳米材料的生物相容性.
- PDA涂层的MOF显示细胞毒性降低,为更安全的纳米医学应用铺平了道路.
- 这项研究强调了PDA修饰的MOF在开发先进药物输送系统中的潜力.
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