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1-多德卡诺伊尔-LSD (1DD-LSD) 的分析和行为特征

Pierce V Kavanagh¹, Folker Westphal², Benedikt Pulver^2,3

¹Department of Pharmacology and Therapeutics, School of Medicine, Trinity Centre for Health Sciences, St. James Hospital, Dublin, Ireland.

Drug testing and analysis

|April 3, 2024

概括

1-多德卡诺伊尔-LSD (1DD-LSD) 是一种新型迷幻化合物,在小鼠中产生类似于LSD的效果,但强度明显低于LSD. 它的效率降低表明无效的体内水解,可能表明长期作用的前药物对未来的人类研究的概况.

科学领域:

药理学药理学是指药理学的学科.
神经科学是一个神经科学.
药用化学医学化学

背景情况:

1-Acetyl-N,N-diethyllysergamide (ALD-52) 是一种类似于LSD的迷幻化合物,充当前药物.
新的lysergamides被合成来探索结构-活性关系,并已成为娱乐药物.
1-多德卡诺伊尔-LSD (1DD-LSD) 是一种新合成的N1-化LSD衍生物.

研究的目的:

为了分析性地描述1DD-LSD.
用小鼠头部抽反应 (HTR) 试验评估1DD-LSD体内迷幻效应.
为了比较1DD-LSD与LSD和其他相关化合物的功效.

主要方法:

1DD-LSD的分析特征.
给C57BL/6J小鼠使用1DD-LSD.
测量头反应 (HTR) 以确定中位有效剂量 (ED50).

主要成果:

1DD-LSD在小鼠中诱导了HTR,ED50为2.17 mg/kg (3.60 μmol/kg).
在HTR试验中,LSD的强度是1DD-LSD的27倍.
1DD-LSD的功效低于其他N1-乙化溶甘胺,如ALD-52和1-propanoyl-LSD.

结论:

1DD-LSD的较低功效表明,与其他N1-化溶解甘氨酸相比,其在体内水解效率较低.
增加1DD-LSD的脂性可能导致脂肪的封存,减少水解和延长效果.
需要进一步的临床研究来评估1DD-LSD在人类中的活性及其作为长效LSD前的潜力.

关键词:

这是一种LSD,一种LSD.头部抽反应的反应新的精神活性物质.迷幻药物迷幻药物是一种精神药物.

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