神经成像改变和复发在早期精神病的精神病
Marina Mihaljevic1, Anisha Nagpal1, Semra Etyemez1
1Departments of Psychiatry (Mihaljevic, Nagpal, Etyemez, Narita, Ross, Schaub, Cascella, Coughlin, Nestadt, Nucifora, Sedlak, Yang, Sawa), Radiology and Radiological Sciences (Faria), Neuroscience (Sawa), Biomedical Engineering (Sawa), Phamarchology (Sawa), and Genetic Medicine (Sawa), Johns Hopkins University School of Medicine; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md. (Sawa); Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, Ga. (Calhoun).
早期精神病的复发与大脑连接的显著变化有关,特别是涉及泰拉马斯. 这些神经成像变化凸显了理解精神病进展中的生物机制的重要性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 早期精神病的复发可能会导致有害的脑部变化和较差的结果.
- 在出现复发的患者中,可能存在实质性的神经成像改变.
研究的目的:
- 为了研究早期精神病患者和那些没有复发的人之间的神经成像差异.
- 为了确定与精神病复发相关的特定大脑连接性改变.
主要方法:
- 休息状态功能性MRI用于分析85名患者 (54例复发,31例不复发) 和94名健康对照患者的功能连接.
- 分析了78个感兴趣的地区之间的3003个功能连接估计,并调整了混因素.
- 患者在第一次精神病发作后2年内进行评估.
主要成果:
- 在47个功能连接估计中,在复发组和对照组之间发现了显著的差异.
- 在没有复发的组和对照组之间没有观察到任何显著差异.
- 64%的改变的连接性涉及丘脑,显示从对照组到无复发到复发组的进展.
结论:
- 神经元连接的病理差异,特别是涉及 thalamus,与早期精神病的复发有关.
- 复发背后的神经生物学机制对于理解精神病障碍的发展轨迹至关重要.
- 需要进一步的纵向研究来证实泰拉马斯在精神病复发中的作用.
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