纳氏血性脂肪炎的流行病学 - 关注糖尿病
Zobair M Younossi1, Linda Henry1
1Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, United States; Center for Liver Disease, Department of Medicine, Inova Fairfax Medical Campus, Falls Church, VA, United States; Center for Outcomes Research In Liver Diseases, Washington, DC, United States.
Diabetes research and clinical practice
|April 3, 2024
概括
非酒精性脂肪性肝病 (NAFLD) 在2型糖尿病 (T2D) 患者中更严重. 识别2型糖尿病的高风险NAFLD患者对于及时,有效的治疗和改善结果至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 非酒精性脂肪肝 (NAFLD) 影响全球38%,在2型糖尿病 (T2D) 患者中患病率和严重程度更高.
- 在NAFLD和T2D的同时发生显著增加了进展性肝病的风险,包括肝硬化和肝细胞癌.
- 非酒精性脂肪肝炎 (NASH) 是一种严重的NAFLD形式,影响了37%的T2D患者.
研究的目的:
- 要突出NAFLD和T2D之间的复杂相互作用.
- 为了强调患有这两种疾病的患者肝脏不良结果的风险增加.
- 倡导风险分层和及时治疗干预措施.
主要方法:
- 对NAFLD和T2D (2016-2019) 全球流行数据的审查.
- 在有或没有T2D的NAFLD患者之间对疾病进展和死亡风险的比较分析.
- 讨论对高风险患者群体的治疗影响.
主要成果:
- 全球NAFLD患病率为38%;70%的T2D患者患有NAFLD,而23%的NAFLD患者患有T2D.
- 患有T2D的NAFLD患者面临的肝硬化,肝细胞癌和全因死亡率的风险要大得多.
- 中东北非和拉丁美洲地区的NAFLD和T2D的负担很高.
结论:
- 由于风险增加,NAFLD和T2D的组合需要积极管理.
- 应在初级保健和内分泌学中实施风险分层算法,以识别高风险个体.
- 建议在高风险的NAFLD患者早期考虑先进的T2D治疗.
相关概念视频
01:20Pathophysiology of Diabetes
926
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
926
01:26Diseases of the Liver and Gallbladder
534
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
534
01:36Carbohydrate Metabolism
11.1K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.1K
01:24Chronic Pancreatitis I: Introduction
87
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
87
01:22Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
01:15Diabetes: Symptoms, Diagnosis, and Complications
530
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
530