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Updated: Jun 29, 2025

Advancing High-Resolution Imaging of Virus Assemblies in Liquid and Ice
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结合100keV冷电子显微镜和图像分析方法来描述更广泛的腺相关病毒产品

Haruka Nishiumi1, Kiichi Hirohata1, Mitsuko Fukuhara2

  • 1Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

Journal of pharmaceutical sciences
|April 3, 2024
PubMed
概括

使用冷电子显微镜的新图像分析方法准确地确定充满到空的腺相关病毒 (AAV) 颗粒的比例. 这一进展对于通过量化空粒子污染来提高基因疗法的有效性和安全性至关重要.

关键词:
腺相关病毒 (AAV)分析超离心法分析超离心法生物制药特征的表征基因治疗是一种基因疗法.图像分析 图像分析机器学习 机器学习形态学 形态学 形态学神经网络 (((s) 是一个神经网络.治疗药物监测 治疗药物监测病毒载体 (病毒载体)

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Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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