相关实验视频

Updated: Jun 29, 2025

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Published on: August 25, 2014

在COVID-19后的低血中,嗅觉通路中没有表现出主要的神经退行性标记物

Tommaso Schirinzi¹, Daniela Maftei², Riccardo Maurizi³

¹Unit of Neurology, Department of Systems Medicine, Tor Vergata University of Rome, Via Montpellier 1, 00133, Rome, Italy. t.schirinzi@yahoo.com.

Molecular neurobiology

|April 3, 2024

概括

持续的COVID-19后嗅觉丧失 (低湿症) 可能不是来自嗅觉神经元的神经退行. 早期分析没有发现这些细胞中存在关键阿尔茨海默氏症或帕金森病标志物的证据.

科学领域:

神经科学是一个神经科学.
病理学病理学病理学
耳鼻喉科耳鼻喉科耳鼻喉科

背景情况:

持续的COVID-19后嗅觉障碍 (低湿症) 有一个不清楚的生物学基础.
嗅觉功能障碍可能是神经退行性疾病的早期症状,表明潜在的中枢嗅觉回路参与.
嗅觉神经元 (ONs) 可以反映大脑病理,为分子事件提供一个窗口.

研究的目的:

为了研究持续的COVID-19后嗅觉损失患者的嗅觉神经元,寻找神经退行症的迹象.
分析ONs对α-synuclein,β-amyloid,tau病理,轴突损伤和线粒体功能障碍的标志物.

主要方法:

通过非侵入性刷毛收集了10名COVID-19后持续性低血 (>6个月) 的患者和10名对照者的嗅觉神经元.
使用免疫光染色来定量蛋白质.
使用RT-PCR用于对特定病理标记物的基因表达分析.

主要成果:

在患者和对照组之间,在ONs水平的寡合性α-synuclein,粉样β或tau蛋白中没有发现显著差异.
神经纤维光链 (NfL),细胞染色体C氧化酶亚单元3 (COX3) 和热冲击蛋白60 (HSP60) 的水平也相似.
结果表明,在COVID-19后早期的低血中,没有证据表明有同核病变,粉样β代谢问题,神经元损伤或线粒体功能障碍.

结论:

持续性COVID-19后低血的早期阶段似乎不是由同核蛋白病变,粉样蛋白-β病理或嗅觉系统内的显著神经元损伤驱动的.
需要进一步的研究,以阐明COVID-19感染后持续的气味丧失背后的精确机制.

关键词:

缺血症是什么意思缺血症是什么意思长时间的COVID.神经退行发生神经退行.嗅觉功能障碍嗅觉功能障碍嗅觉神经元是一种神经元.后COVID的情况

更多相关视频

Author Spotlight: Assessing the Olfactory Effects of Airborne Pollutants — Buried Food and Social Odor Tests

Author Spotlight: Assessing the Olfactory Effects of Airborne Pollutants — Buried Food and Social Odor Tests

Published on: September 13, 2024

A Free-breathing fMRI Method to Study Human Olfactory Function

A Free-breathing fMRI Method to Study Human Olfactory Function

Published on: July 30, 2017

相关概念视频

Olfactory Receptors: Location and Structure

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...

Olfaction

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...

Physiology of Smell and Olfactory Pathway

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...