富含黄的三叶草 (Trianthema decandra) 改善了高血糖大鼠的认知功能障碍
Sayyada Saleha Momina1, Kumaraswamy Gandla2
1Department of Pharmacognosy and Phytochemistry, Chaitanya (Deemed to be University), Gandipet, HimayathNagar (Vill), Hyderabad, Telangana, 500075, India.
Biochemical genetics
|April 3, 2024
概括
甲醇提取物Trianthema decandra (METD) 显示显著的神经保护作用,对大鼠高血糖引起的认知障碍. 这项研究强调了其作为糖尿病相关大脑健康问题的天然疗法的潜力.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 神经科学是一个神经科学.
- 自然产品化学 自然产品化学
背景情况:
- 过高血糖与认知障碍有关,造成严重的健康问题.
- 传统的药用植物正在越来越多地研究其治疗潜力.
- 特里安瑟马被探索其生物活性化合物和健康益处.
研究的目的:
- 为了评估三甲虫的甲醇提取物 (METD) 的神经保护能力.
- 在大鼠模型中评估METD对高血糖相关认知障碍的疗效.
- 为了调查Trianthema decandra成分的抗糖尿病和神经保护作用.
主要方法:
- 使用薄层染色学 (TLC) 和高性能薄层染色学 (HPTLC) 标准化Trianthema decandra提取物.
- 在体外评估α-氨酶和α-葡萄糖酶抑制.
- 在糖尿病大鼠中使用莫里斯水迷宫 (MWM) 和升高加迷宫 (EPM) 模型进行体内评估,并测量乙胆酶 (AChE) 活性.
主要成果:
- 特里安瑟马的提取物,特别是甲醇和酒,显示出显著的α-氨酶和α-葡萄糖酶抑制.
- 已识别的成分,Quercetin和phytol,与甲醇和酸盐提取物有关.
- 在糖尿病大鼠中,METD (200和400 mg/kg) 给药降低了高血糖,高脂血症,并在MWM和EPM测试中改善了认知功能.
结论:
- 特里安瑟马的提取物具有显著的抗糖尿病和神经保护性质.
- 已识别的化合物,素和植物素,有助于提取物的治疗作用.
- METD显示了管理高血糖相关认知缺陷的潜力.
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