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Updated: Jun 29, 2025

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PBPK-PD模型用于预测人类的吗啡药理动力学,中枢神经系统影响和纳洛对抗性

Rui-Jing Mu1, Tian-Lei Liu1, Xiao-Dong Liu2

  • 1Department of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.

Acta pharmacologica Sinica
|April 3, 2024
PubMed
概括

一个新的生理学基础的药理动力学-药理动力学 (PBPK-PD) 模型准确地预测了吗啡及其代谢物吗啡-6-葡萄糖 (M6G) 以及纳洛对中枢神经系统 (CNS) 的影响.

关键词:
这是一个PBPK-PD模型.止痛药 止痛药 止痛药 止痛药 止痛药肌肉分裂 (miosis) 是一种疾病.这是吗啡吗啡.纳洛 (Naloxone) 是一种药物.呼吸系统的抑郁症 呼吸系统的抑郁症

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