在21年的随访研究中,不下降的血压模式与心血管事件有关
Päivi A Lempiäinen1, Antti Ylitalo2, Heikki Huikuri3
1Medical Research Center Oulu, Oulu University Hospital and Research Unit of Biomedicine and Internal Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland. paivialempiainen@gmail.com.
Journal of human hypertension
|April 3, 2024
概括
保持不下降的血压模式显著增加心血管事件的风险. 这种持续的非浸泡状态,即使是正常的血压水平,也是长期心血管结果的关键独立预测指标.
科学领域:
- 心脏病学 心脏病学
- 高血压研究 高血压研究
- 预防医学 预防医学
背景情况:
- 不下降的血压 (BP) 是心血管 (CV) 事件和死亡率的公认预测指标.
- 了解浸泡状态随时间的变化对于评估长期心血管风险至关重要.
研究的目的:
- 在长期跟踪期间评估浸泡状态的变化.
- 评估浸泡状态变化与中年人群中非致命CV事件发生率之间的关联.
主要方法:
- 利用了来自OPERA研究的数据,其中包括来自两个调查的24小时门诊血压测量 (ABPM) (1991-1993年和21.7年后).
- 根据浸泡模式的变化,将452名参与者分为四组:浸泡-浸泡,浸泡-不浸泡,不浸泡-浸泡和不浸泡-不浸泡.
- 采用考克斯回归分析,调整传统心血管风险因素,以确定浸泡模式和心血管事件之间的关联.
主要成果:
- CV 事件的发生率在不浸泡-不浸泡组 (28%) 与浸泡-浸泡组 (6.6%) 相比显著更高.
- 在对共变量进行调整后,非浸泡-非浸泡模式仍然是CV事件 (HR 4.01) 的重要独立预测指标.
- 非浸泡-非浸泡模式与心血管事件之间的关联独立于办公室和门诊血压水平以及其他常规风险因素.
结论:
- 持续不下降的血压模式与长期增加非致命心血管事件的发病率密切相关.
- 非浸泡-非浸泡模式代表了心血管事件的独立风险因素,强调了监测血压变化的重要性.
- 这些发现凸显了需要将血压下降状态视为心血管风险评估和管理中的关键因素.
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