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在雄性大鼠中,侧向中侧体核通过腹部体区域输出来阻止脂肪的过度消耗

Florian Schoukroun¹, Katia Befort², Romain Bourdy³

¹Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), Université de Strasbourg, UMR7364, CNRS, 12 Rue Goethe, 67000, Strasbourg, France.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

|April 3, 2024

概括

侧向中侧质核 (RMTg) 影响可口的食物摄入量和复发. 损伤RMTg-VTA通路增加了脂肪消耗,而RMTg-LH通路损伤减少了总体热量摄入.

科学领域:

神经科学是一个神经科学.
行为神经科学行为神经科学
肥胖问题研究研究

背景情况:

过度摄入高脂肪,高糖食物会通过激活大脑的奖励回路来驱动肥胖.
介内膜奖励回路中的神经适应与饮食障碍和肥胖有关.
作为一种抑制性结构的侧向介质质质核 (RMTg) 投射到调节食物摄入的关键区域,但其作用尚未得到充分研究.

研究的目的:

研究RMTg及其对腹膜区域 (VTA) 和侧下丘脑 (LH) 的投射在调节食物摄入中的作用.
检查RMTg通路病变如何影响老鼠的食用食物消费和复发行为.

主要方法:

鼠经历了RMTg的双边刺激性损伤或特定的RMTg-VTA和RMTg-LH通路损伤.
动物接受了为期6周的可口饮食,随后被强迫戒断和24小时的重新接入期.

主要成果:

RMTg-VTA通路的损伤显著增加了饮食后和重新进入期间的脂肪消耗.
RMTg-LH通路的损伤导致总体卡路里摄入量适度下降.
这些发现凸显了RMTg参与控制可口食物摄入量和复发的作用.

结论:

RMTg在调节可口食品消费和复发行为方面发挥着至关重要的作用.
RMTg对食物摄入的影响通过其对VTA和LH的预测进行调解.
准RMTg-VTA通路可能为管理肥胖和饮食障碍提供治疗潜力.

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