维生素D状态,维生素D受体多态性和2型糖尿病风险:前性队列研究
Yanqi Fu1, Meng Lu2, Kun Zhang1
1Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
The Journal of clinical endocrinology and metabolism
|April 4, 2024
概括
较高的维生素D水平与正常血糖或糖尿病前期血糖的个体的2型糖尿病风险降低有关. 遗传因素和改善的甘油三水平在这种关联中起作用.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 遗传学 是一个遗传学.
背景情况:
- 维生素D状态与2型糖尿病 (T2D) 风险有关.
- 关于这种关联如何随着血糖状况变化存在有限的证据.
研究的目的:
- 为了检查血清25-基维生素D (25(OH) D) 与发生T2D风险在整个血糖谱中的潜在关联.
- 研究维生素D受体 (VDR) 遗传变异对这种关联的修饰作用.
主要方法:
- 在基线没有T2D的379,699名英国生物库参与者的前性研究.
- 根据血糖状况和HbA1c水平分层分析.
- 考克斯比例危险模型用于计算危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 在正常血糖和糖尿病前期组中,较高的血清25(OH) D (≥75nmol/L) 与较低的水平 (<25nmol/L) 相比,与降低的T2D风险 (HRs~0.62-0.64) 有关.
- 在糖尿病前期观察到的25(OH) D和VDR多态性 (rs1544410) 之间的显著相互作用,T等位基因载体的风险降低更大.
- 在正常血糖和糖尿病前期的个体中,三甘水平介导了25%的OH) D-T2D关联的26%和34%.
结论:
- 血清25(OH) D度升高与糖尿病值以下的血糖水平的T2D风险降低相关.
- 糖尿病前期维生素D和T2D风险之间的关系受VDR遗传变异的影响.
- 脂质特征的改善,特别是甘油三,有助于维生素D所观察到的保护作用.
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