从基数对到城市广场:未来的全面精确瘤学
Amy E Leader1, Christopher M McNair1, Jennifer M Johnson1
1Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
Cancer discovery
|April 4, 2024
概括
了解健康的社会决定因素 (SDOH) 可以改善癌症的预防和治疗. 将SDOH与遗传学相结合,创造了一个全面的精确瘤学框架,以改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 遗传学 是一个遗传学.
背景情况:
- 健康的社会决定因素显著影响癌症预防,治疗和患者的结果.
- 当前的精确瘤学框架往往忽视了社会和环境因素的影响.
研究的目的:
- 强调健康的社会决定因素在瘤学中的重要性.
- 倡导将健康的社会决定因素纳入精确瘤学.
- 为制定有针对性的干预和临床试验提供信息.
主要方法:
- 文献综述和现有关于健康和癌症的社会决定因素研究的综合.
- 对当前精确瘤学方法的分析.
- 概念框架的发展.
主要成果:
- 增加对SDOH在癌症治疗连续性中的作用的理解.
- 确定将SDOH整合到遗传学和基因组学中的机会.
- 全面精确瘤学的框架.
结论:
- 将健康的社会决定因素与遗传学和基因组学相结合,对于一个全面的精确瘤学框架至关重要.
- 这种整合将为更有效的干预和临床试验提供信息.
- 与基因组数据一起解决SDOH将改善癌症预防和患者的治疗结果.
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