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民主化下一代瘤学临床试验的愿景

Vivek Subbiah¹, Denis Horgan², Ishwaria M Subbiah^1,3

¹Sarah Cannon Research Institute, Nashville, Tennessee.

Cancer discovery

|April 4, 2024

概括

瘤学临床试验需要改革,以改善获得新癌症疗法的机会,并增加参与者的多样性. 创建包容性,全球癌症研究倡议的合作方法至关重要.

科学领域:

在瘤学瘤学.
临床试验临床试验
健康公平卫生公平

背景情况:

在癌症治疗方面取得了重大进展.
目前的临床试验系统面临诸如获得新疗法的限制等挑战.
临床试验参与者之间显著缺乏多样性.

研究的目的:

为民主化瘤学临床试验概述一个愿景.
倡导全球可访问的癌症研究.
解决阻碍公平参与的障碍.

主要方法:

概念框架的发展.
关于临床试验挑战的文献综述.
利益相关者分析 (研究人员,临床医生,患者,决策者).

主要成果:

确定了当前瘤学试验获取和多样性的关键挑战.
提出了一个包容性试验设计的协作模式.
强调需要对试验行为进行系统性改变.

结论:

将复杂的,独家的试验转化为动态的,包容性的举措至关重要.
为了在癌症研究中实现全球卫生公平,需要多部门的合作.
实现民主化的瘤学试验需要研究实践的范式转变.

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