相关实验视频
Updated: Aug 16, 2026
07:50
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
5.5K
与热致死相关的基因特征用于预测胃癌的预后
Salem Saeed Saad Khamis1, Jianhua Lu1, Yongdong Yi1
1The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Frontiers in oncology
|April 4, 2024
概括
胃癌 (GC) 风险可以通过调节热的基因来预测. 低风险得分表明更好的生存率,而高风险患者表现出改变的免疫活性,这表明烧死基因是GC的关键预后指标.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 胃癌 (GC) 是一种异质恶性瘤,需要改进预测模型.
- 杆菌感染可以诱导热,这是一种与GC相关的致癌过程.
- 化疗是胃癌的常见治疗方法.
研究的目的:
- 开发一种用于胃癌预后的预测模型,使用灭调节基因.
- 评估GC中与热相关的基因的预测相关性.
- 为了研究热致死,免疫反应和GC结果之间的关系.
主要方法:
- 对瘤中的17种烧灭细胞调节蛋白的分析与正常胃组织的分析.
- 利用癌症基因组图集 (TCGA) 和基因表达总汇 (GEO) 队列进行验证.
- 应用最小绝对收缩和选择操作员 (LASSO) 回归用于基因选择和风险评分发展.
主要成果:
- 一个基于pyroptosis基因的风险评分显著地将GC患者分为低风险和高风险组.
- 在TCGA (P<0.0001) 和GEO (P=0.0063) 队列中,低风险患者的整体存活率 (OS) 显著提高.
- 高风险组基因与免疫活性升高,但免疫状态降低有关,表明复杂的免疫癌症相互作用.
结论:
- 烧调节基因作为胃癌存活率的重要独立预后因素.
- 开发的风险评分有效地预测了GC中的患者结果.
- 在GC中,火和免疫反应之间的相互作用表明有针对性的免疫疗法的潜力.
相关概念视频
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:33Cancer-Critical Genes I: Proto-oncogenes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
02:59Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:11Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
01:21Cancer Survival Analysis
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...