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在老年患者的大型腹部手术后,单细胞的代谢变化和术后发病率:前性队列研究

Yi Zhao¹, Mengchan Ou¹, Xuechao Hao¹

¹Department of Anesthesiology, and the Research Units of West China (2018RU012) - Chinese Academy of Medical Sciences, West China Hospital of Sichuan University, Sichuan University, Chengdu, China.

|April 4, 2024

概括

手术期间单细胞的代谢变化可以预测老年患者的术后并发症. 具体来说,糖溶性储备的变化预测了不良结果,为风险识别提供了新的见解.

科学领域:

老年医学老年医学
手术瘤学手术瘤学
代谢研究研究代谢研究

背景情况:

老年患者的术后并发症增加了成本和痛苦.
能量代谢的改变与衰老和手术有关,但它们对并发症的预测作用尚不清楚.
这项研究调查了手术期间的代谢变化作为老年患者术后并发症的预测因素.

研究的目的:

为了确定手术期间的代谢变化是否预测老年患者的术后并发症.
为了确定与老年人不良手术结果相关的特定代谢标志物.
探索单细胞能量代谢在手术风险分层中的作用.

主要方法:

一项针对244名65岁以上的成年人进行的前性观察队列研究,这些成年人接受了可选的大型非心脏手术.
手术前和后收集的血液样本.
测量单细胞氧气消耗率 (OCR) 和细胞外酸化率 (ECAR),以评估细胞代谢.

主要成果:

分别在OCR和ECAR组中的12.7%和12.3%的患者出现了中度至严重的并发症.
手术后的葡萄糖分解在单细胞中加剧.
糖溶性储备 (GR) /糖溶性 (G) 和GR/非糖溶性酸化 (NG) 的变化预测了并发症 (AUC=0.70和0.67).
术后GR/G的减少与更糟糕的结果有关 (RR=9.08).

结论:

在大手术后预测术后并发症方面,单细胞甘油性功能变化比线粒体功能更有价值.
这项研究为识别高风险老年患者提供了新的见解.
单细胞的代谢分析可能会提高老年人群的术后风险评估.

关键词:

腹部外科手术腹部外科手术老年患者的患者.代谢变化代谢变化术后并发症术后并发症风险评估风险评估风险评估

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