中度至重度的酒精消费可能会导致中年妇女的血清高密度脂蛋白胆固醇显著降低:国家数据库研究的队列研究在坎托省的7个县-4-4-4
Airi Sekine1, Kei Nakajima1,2
1Department of Food and Nutrition, Japan Women's University, Tokyo, JPN.
Cureus
|April 4, 2024
概括
习惯性中度至重度饮酒与中年女性高密度脂蛋白胆固醇 (HDL-C) 的降低有关. 在一项大型队列研究中,使用统计和人工智能分析确定了这种关联.
科学领域:
- 心血管健康 心血管健康
- 营养流行病学 营养流行病学
- 人工智能在医学中的应用
背景情况:
- 对女性习惯性饮酒与血清高密度脂蛋白胆固醇 (HDL-C) 之间的关系的了解有限.
- 调查这种关联对于关于酒精消费和心血管风险的公共卫生建议至关重要.
- 中年女性是研究影响胆固醇水平的生活方式因素的关键人口.
研究的目的:
- 在中年日本妇女中,研究习惯性饮酒与血清HDL-C10年变化之间的关联.
- 利用传统的统计方法和可解释的人工智能 (AI) 进行全面分析.
- 确定导致HDL-C水平下降的潜在因素.
主要方法:
- 追溯队列研究涉及90,053名年龄在40-64岁之间的日本女性,她们在10年内一直保持饮酒习惯.
- 在基线和10年后分析血清HDL-C水平.
- 应用传统的统计分析和可解释的AI来评估酒精消费和其他因素对HDL-C变化的影响.
主要成果:
- 中度 (每天23-45克) 和重度 (每天≥46克) 的酒精消费与10年后的HDL-C (≥10 mg/dL或≥10%) 降低显著相关.
- 通过AI分析,酒精消费被确定为HDL-C下降的第8个积极贡献者,其次是基线HDL-C,LDL-C,BMI和吸烟等因素.
- 与其他水平相比,大量饮酒对HDL-C下降的贡献更大.
结论:
- 习惯性中度至重度饮酒可能导致中年妇女血清HDL-C显著下降.
- 同时的因素可以改变酒精对HDL-C水平的影响.
- 研究结果强调了考虑酒精摄入量在管理女性胆固醇和心血管健康的策略中的重要性.
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