尼姆玻利德:预防和治疗慢性疾病的有希望的药物 (最近的更新)
Peramaiyan Rajendran1,2, Kaviyarasi Renu2, Basem M Abdallah1
1Department of Biological Sciences, College of Science, King Faisal University, Al Ahsa, Saudi Arabia.
Food & nutrition research
|April 4, 2024
概括
尼姆树的化合物尼姆玻利德 (Nimbolide) 由于其抗炎和抗癌作用,对治疗慢性疾病充满希望. 研究强调了其调节关键分子通路的能力,这些通路涉及到诸如心血管疾病和癌症等疾病.
科学领域:
- 药理学 药理学是指药理学的学科.
- 自然产品 自然产品
- 慢性疾病管理 慢性疾病管理
背景情况:
- 尼姆树 (Azadirachta indica) 的生物活性化合物Nimbolide具有显著的抗炎,抗氧化和抗癌特性.
- 传统上在医学中使用,Nimbolide正在研究其在管理慢性疾病的潜力,如心血管疾病,糖尿病和癌症.
- 最近的研究强调了尼姆博莱德的多方面的药理作用,将其定位为有前途的治疗剂.
研究的目的:
- 在慢性疾病中审查尼姆博莱德治疗效应的分子机制.
- 巩固当前关于尼姆博莱德有效性和在疾病预防和治疗中的潜在应用的研究.
- 探索 nimbolide 在调节慢性疾病相关的关键信号通路中的作用.
主要方法:
- 在包括MEDLINE,Embase,Scopus和知识网络在内的主要数据库中进行了全面的文献搜索.
- 搜索的重点是到2020年9月发表的研究.
- 该审查集中在了解尼姆博莱德治疗作用的分子机制上.
主要成果:
- 尼姆树中的一种强效的利莫诺伊德Nimbolide调节了关键的信号通路,如MAPKs,Wnt-β/catenin,NF-κB和PI3K/AKT.
- 它影响信号分子,包括TGF-β,MMP,VEGF,炎症细胞因子和EMT蛋白.
- 尼姆玻利德具有抗炎,抗微生物和抗癌特性,在骨关节炎,类风湿性关节炎,心血管疾病和癌症中显示出治疗潜力.
结论:
- 尼姆玻利德是一种有前途的天然化合物,具有治疗一系列慢性疾病的巨大潜力.
- 它的有效性源于其调节关键分子和信号通路的能力,这些通路参与了疾病的发病.
- 对尼姆博莱德分子机制的进一步研究可以为创新的治疗策略铺平道路.
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