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败血症引起的心肌功能障碍在儿科败血症休克:流行率,预测因素和结果-一个前性观察性研究
Viresh S Swami1, Lalitha A V2, Santu Ghosh3
1Dr. Bidari's Ashwini Institute of Child Health and Research Centre, Vijayapur, Karnataka, India.
Journal of pediatric intensive care
|April 4, 2024
概括
败血症引起的心肌功能障碍 (SMD) 影响32%的患有败血症休克的儿童,显著增加死亡风险. 早期检测使用 point-of-care 功能性心声学和监测乳酸水平可以改善结果.
科学领域:
- 儿科重症监护医学 儿科重症监护医学
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
背景情况:
- 败血症引起的心肌功能障碍 (SMD) 在儿科败血症休克中没有得到研究.
- 关于其患病率,预测因素和预后标志物的数据有限.
研究的目的:
- 为了估计小儿性休克中SMD的患病率,使用护理点功能性心声回声学 (POCFE).
- 调查SMD与疾病严重程度,器官功能障碍和患者结局的关联.
- 确定SMD的预测因子和预后标志物.
主要方法:
- 在印度南部的小儿重症监护室 (PICU) 进行了前性观察性研究.
- 报名的儿童患有败血性休克,在PICU入院6小时内执行POCFE.
- 根据POCFE发现对SMD诊断进行分类的患者.
主要成果:
- 乳腺癌的患病率为32% (32/100名儿童).
- 与非SMD组 (7.5%) 相比,SMD组的死亡率明显高 (54.5%).
- SMD与器官功能障碍增加相关,结果更差,并且是死亡率的独立预测因素. 6小时后的乳酸盐水平 (值2.4 mmol/L) 预测了SMD,敏感度为73%,特异性为80%.
结论:
- SMD是儿科败血症休克的一个显著而非罕见的并发症.
- SMD与增加的死亡率,器官功能障碍和较差的患者结果有关.
- 乳酸的趋势可以作为宝贵的预后标志物SMD在儿科败血症休克.
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