尿中化物分泌 儿科患者心肺后绕道-试点研究
Sophie Fincher1,2, Kristen Gibbons2,3, Kerry Johnson1,2,3
1Department of Pediatric Intensive Care, Queensland Children's Hospital, Brisbane, Australia.
Journal of pediatric intensive care
|April 4, 2024
概括
在心肺旁路手术 (CPB) 后,儿科患者的尿液化物分泌受损. 这表明功能障碍,特别是氨处理受损,手术后逐渐恢复.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 儿科重症监护 儿科重症监护
- 心血管外科心血管外科
背景情况:
- 心肺绕道 (CPB) 手术是儿科心脏手术中的关键干预.
- 功能和电解质平衡在CPB后至关重要,特别是在新生儿和婴儿中.
- 化物代谢在酸平衡和功能方面发挥着重要作用.
研究的目的:
- 在CPB手术后的儿科患者中调查脏化物代谢.
- 分析尿液和血化物和强离子差异 (SID) 在早期术后期的变化.
- 探索化物水平与CPB后急性损伤之间的潜在关联.
主要方法:
- 在儿科重症监护室 (PICU) 进行前性观察性研究.
- 招募了20名接受CPB手术的儿科患者 (<2岁).
- 收集序列性尿液和血电解质,尿素,肌素和血液气体.
- 计算了尿液和血强离子差异 (SID).
- 监控液体平衡和电解质的使用.
主要成果:
- 尿液中化物分泌量在CPB后显著降低,在24小时内保持在基线以下.
- 血中化物水平在入院后降低,但仍在正常范围内.
- 尿路SID在CPB后显著增加,在6小时达到峰值,并保持48小时升高.
- 血或尿液中化物度与急性损伤发展之间没有发现关联.
结论:
- 在儿科患者中,CPB后尿路化物分泌受损.
- 观察到尿路SID的增加表明,CPB后的氨产量和/或氨分泌受损.
- 化的脏代谢在术后逐渐恢复,但明显的发现是排泄受损.
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