新兴的瘤微生物微环境:从划界到基于多学科方法的干预措施
Yu Fu1, Jia Li2, Wenyun Cai1
1Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Acta pharmaceutica Sinica. B
|April 4, 2024
概括
内微生物群通过影响瘤开始,转移和治疗反应,显著影响癌症. 了解这种瘤微生物微环境对于开发基于微生物的新型癌症疗法至关重要.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 内微生物群是瘤微环境 (TME) 的一个关键组成部分.
- 瘤中的微生物影响瘤的发病,转移,免疫监测和预后.
- 瘤微生物微环境具有独特的特征,与传统的TME不同.
研究的目的:
- 审查内微生物群在各种癌症中的异质性和作用.
- 确定瘤微生物微环境的特征,包括PAMPs,代谢物和免疫调节.
- 探索针对瘤微生物组的癌症治疗的多学科方法.
主要方法:
- 文献综述侧重于内微生物群及其功能.
- 分析微生物成分,代谢物及其对TME的影响.
- 检查涉及活微生物,代谢物,抗生素和生物材料的治疗策略.
主要成果:
- 内微生物群在不同瘤类型中表现出异质性.
- 微生物成分和代谢物调节炎症,免疫力和化学抵抗力.
- 多学科干预措施显示出癌症治疗的前景.
结论:
- 对瘤微生物微环境的全面理解是必不可少的.
- 针对癌症-免疫-微生物相互作用提供了新的治疗途径.
- 基于微生物的策略具有开发瘤特定癌症治疗的潜力.
关键词:
自自是一种自的过程.化学抗药性 化学抗药性是一种抗药性.基因工程微生物群是基因工程微生物群.免疫调节是一种免疫调节.微生物群的代谢物.这是一个多学科的方法.外膜囊泡是外膜囊泡中的一个.瘤微生物 微环境更多相关视频
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