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Updated: Jun 29, 2025

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开发mRNA疫苗的新型深度生成模型:设计5' UTRs与1 - 甲基 - 伪乌里丁修饰

Xiaoshan Tang1, Miaozhe Huo2, Yuting Chen1

  • 1Institute of Systems Genetics, Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610000, China.

Acta pharmaceutica Sinica. B
|April 4, 2024
PubMed
概括

设计最佳的5'非翻译区域 (UTR) 对于N1-甲基-伪氨基酸修饰mRNA疫苗至关重要. 一个新的机器学习工具,Smart5UTR,识别出优异的5' UTR,提高了针对SARS-CoV-2变种的疫苗疗效.

关键词:
5′ UTR 5′ UTR 的时间表.在 COVID-19 疫情中,机器学习是机器学习.这是一种N1-甲基伪尤里丁.这就是SARS-CoV-2病毒.序列设计的设计方式mRNA 设计的设计这是mRNA疫苗.

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