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评估TNF-α (-857 C/T) 基因多态性在口腔平坦菌病:一个病例对照研究

Mohammad Hesam Marabi¹, Kheirollah Yari¹, Hamid Reza Mozaffari²

¹Molecular Genetics Laboratory, Medical Biology Research Center, Health Technology Institute Kermanshah University of Medical Sciences Kermanshah Iran.

Health science reports

|April 4, 2024

概括

这项研究发现,在伊朗人群中,瘤亡因子-alpha (-857 C/T) 基因多态化和口腔平坦 (OLP) 之间没有显著的关联. 单核酸多态性TNF-α (-857 C/T) 似乎没有影响OLP风险或亚型.

科学领域:

免疫遗传学免疫遗传学
口腔医学是指口腔医学.
分子生物学分子生物学

背景情况:

口腔平坦 (OLP) 是一种免疫媒介的炎症性粘膜皮肤疾病.
在OLP患者中观察到血清瘤坏死因子-α (TNF-α) 水平升高.
目前正在研究TNF-α (-857 C/T) 多态因其在调节TNF-α水平方面的潜在作用.

研究的目的:

在伊朗人群中调查TNF-α (-857 C/T) 多态和OLP之间的关联.
确定这种遗传变异是否与OLP发病率增加或特定的OLP亚型相关.

主要方法:

从100名OLP患者和100名健康对照人群收集的唾液样本.
使用聚合酶链反应与对立的两对原始体进行TNF-α (-857 C/T) 多态的DNA提取和基因型定型.
使用SPSS版本16进行的统计分析.

主要成果:

在OLP患者和对照人群之间,TNF-α (-857 C/T) 基因型 (C/C,C/T,T/T) 的频率没有显著差异.
在两组之间观察到异基因 (p=0.32) 和基因型 (p=0.62) 频率的微不足道差异.
在TNF-α (-857 C/T) 多态和OLP亚型之间没有发现显著的关联.

结论:

在研究的伊朗人群中,TNF-α (-857 C/T) 单核酸多态性与OLP发病率没有显著的关联.
这种特定的遗传变异似乎不是发展OLP或其亚型的风险因素.

关键词:

在OLP,OLP是OLP.这是PCR-CTPPPP.在SNP中,SNP是SNP.这就是TNF-α.遗传多形态主义是一种遗传多形态主义.

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