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Updated: Jun 29, 2025

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
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使用无对齐自然向量方法自动识别染色体融合

Hongyu Yu1, Stephen S-T Yau1,2

  • 1Department of Mathematical Sciences, Tsinghua University, Beijing, China.

Frontiers in genetics
|April 4, 2024
PubMed
概括

这项研究引入了一种新的,无对齐的算法,用于识别染色体融合,这是结构变化的关键类型. 新方法更快,不需要手动注释,提高了基因组研究的效率.

关键词:
库恩-蒙克雷斯算法 库恩-蒙克雷斯算法没有对齐的自由对齐.自动识别自动识别自动识别染色体融合是因为染色体的融合.自然载体的自然载体.

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FISH - Fluorescent In-situ Hybridization

Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...
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