利尿剂使用和血清酸盐:鹿特丹研究和英国生物银行
Ariadne Bosman1, Natalia Campos-Obando1, Catherine E de Keyser2
1Department of Internal Medicine, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The Netherlands.
Journal of the Endocrine Society
|April 4, 2024
概括
酸性利尿剂,但不是循环利尿剂,与血清酸盐降低和低酸血症风险增加有关,特别是在较高的BMI的情况下. 这些发现强调了 thiazides 是低酸盐血症的关键因素.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 低酸盐血清水平低 (<0.80 mmol/L) 的特征是低酸盐血清,与肌肉骨问题有关.
- 化物和循环利尿剂通常与导致低酸血症有关,但基于人口的数据仍然有限.
研究的目的:
- 调查使用 thiazide 和循环利尿剂与血清酸盐水平之间的关联.
- 在基于人口的队列中检查利尿剂使用与低酸血症风险之间的关系.
主要方法:
- 在鹿特丹研究 (RS) 和英国生物银行 (UKBB) 队列中进行了横截式多变量线性和后勤回归分析.
- 包括没有慢性病的参与者,根据年龄,性别,体重指数 (BMI) 和可用的血清量进行调整.
主要成果:
- thiazide 利尿剂与血清酸盐的降低和低酸血的可能性增加有显著的关联,特别是在女性中.
- 通过BMI调整减轻了相关性,并且在UKBB的男性中观察到由 thiazide 诱导的低酸血症风险.
- 循环利尿剂与女性血清酸盐的降低有关,但在BMI调整后,这种关联和低酸血症的增加几率失去了意义.
结论:
- 与循环利尿剂相比, thiazide 利尿剂被认为是导致低酸血症的重要因素.
- 增加的BMI和减少的血清也应考虑在患有低酸血症的患者.
- 需要进一步的研究来证实这些发现,并探索低血的潜在调解作用.
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