功能性肠道疾病患者胆酸代谢的改变:一个病例对照研究
Serhii Polishchuk1, Artem Neverovskyi1, Vadym Shypulin1
1Department of Internal Medicine No. 1, Bogomolets National Medical University, Kyiv, Ukraine.
Przeglad gastroenterologiczny
|April 4, 2024
概括
患有腹刺激性肠综合征 (IBS-D) 的患者表现出胆酸 (BA) 代谢发生变化,与症状严重程度有关. 这些发现强调BA吸收不良是IBS-D的关键因素,影响肠道健康和患者体验.
科学领域:
- 胃肠病学 胃肠病学
- 代谢医学是一种代谢医学.
- 微生物组研究 微生物组研究
背景情况:
- 胆酸 (BA) 吸收不良是慢性腹的一个未被认可的原因,可能会影响多达50%的肠功能障碍患者.
- 刺激性肠综合征与腹 (IBS-D) 是一种常见的功能性肠道疾病,其中BA吸收不良可能发挥重要作用.
研究的目的:
- 在被诊断患有刺激性肠综合征 (IBS) 的患者中调查和评估胆酸 (BA) 代谢的指标.
- 探索改变BA代谢与IBS症状的临床表现和严重程度之间的关联.
主要方法:
- 一项涉及28名健康对照,108名IBS-D患者和37名IBS有便秘 (IBS-C) 患者 (18-44岁) 的研究.
- 使用症状问卷 (VSI,FBDSI) 进行评估,并通过HPLC-MS测量血清和便BA (sBA,fBA).
- 使用UPLC-MS.评估肠道细菌胆汁盐化酶 (BSH) 的相对活性 (RA).
主要成果:
- 与对照组和IBS-C患者相比,IBS-D患者表现出较高的初级sBA和fBA,以及较低的二级sBA和fBA百分比 (p <0.01).
- 肠道细菌BSH的相对活性 (RA) 在IBS-D组明显较低 (p <0.01).
- 改变的BA代谢参数 (BSH的RA,二次BA,初级BA,总fBA) 与症状严重程度,内脏敏感性和便特征 (p <0.05) 有显著的相关性.
结论:
- 患有IBS-D的患者在胆酸 (BA) 代谢中表现出明显的改变.
- 这些代谢变化与IBS-D患者的临床症状严重程度,疾病严重程度,内脏敏感性和便参数显著相关.
- 这些发现强调了在IBS-D的病理生理学和管理中考虑BA吸收不良的重要性.
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