摄入酸盐会减轻冷空气暴露期间血压的增加:双盲,安慰剂控制,随机,交叉试验
Samantha N Rowland1, Emma O'Donnell1, Lewis J James1
1School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom.
Journal of applied physiology (Bethesda, Md. : 1985)
|April 4, 2024
概括
饮食中酸盐补充剂,特别是从甜菜汁中补充,在凉爽的条件下更有效地提高血中酸盐水平. 这种酸盐摄入还有助于减轻寒冷期间血压 (BP) 的上升.
科学领域:
- 环境生理学环境生理学
- 心血管生理学心血管生理学
- 营养生物化学 营养生物化学
背景情况:
- 众所周知,暴露于寒冷会增加血压 (BP) 和唾液流量 (SFR).
- 在寒冷条件下增加SFR可能会增强口服酸盐转化为酸盐,从而可能改善氧化的生物可用性.
- 在不同温度下调节血压和亚酸盐水平的食酸盐补充剂的有效性尚未完全理解.
研究的目的:
- 为了研究食酸盐补充剂是否会在凉爽的条件下比在正常热的条件下更有效地增加血酸盐并降低血压.
- 为了确定冷暴露对酸盐代谢的影响及其随后对心血管参数的影响.
主要方法:
- 十二名健康的男性参与了一项涉及四次实验室会议的研究.
- 参与者摄入了富含酸盐 (甜菜汁) 或缺乏酸盐 (安慰剂) 的饮料.
- 测量SFR,血亚酸盐和BP是在常温 (28°C) 或冷 (20°C) 环境温度下进行的,时间长达3小时.
主要成果:
- 在和安慰剂条件下,与正常热条件相比,冷暴露期间的唾液流速在和安慰剂条件下都增加.
- 在凉爽条件下 (592 nM) 饮用甜菜汁后,与正常热条件 (410 nM) 相比,3小时后的血亚酸盐水平显著更高.
- 在安慰剂组中,静态血压 (SBP) 在冷暴露期间增加,但在甜菜汁组中减弱,这表明有保护作用.
结论:
- 与正常热条件相比,在凉爽条件下饮用甜菜汁在增加血亚酸盐方面更有效.
- 急性酸盐摄入会减轻与急性冷空气暴露相关的缩血压升高.
- 这些发现表明,环境温度影响酸盐代谢,酸盐补充剂可以减轻寒冷中的心血管应变.
更多相关视频
05:46A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
4.8K
08:21Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations
Published on: July 21, 2023
1.3K
相关概念视频
01:16Antianginal Drugs: Nitrates and β-Blockers
580
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
580
01:23Antihypertensive Drugs: Vasodilators
516
Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
516
01:28Nitric Oxide Signaling Pathway
5.0K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
5.0K
01:17Measurement of Blood Pressure
924
Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
924
01:28Special considerations while measuring blood pressure
722
When assessing blood pressure (BP), healthcare professionals must consider various factors and potential unexpected outcomes to ensure accurate readings and provide proper patient care. Adhering to these guidelines is essential to achieving the most reliable results.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
722
01:18Disorders of the Autonomic Nervous System
633
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
Raynaud's disease, also known as Raynaud's...
633