严重脑静脉血栓症患者减压手术的结果:DECOMPRESS2观察性研究
Sanjit Aaron1, Jorge M Ferreira2, Jonathan M Coutinho3
1Neurology Unit, Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, Tamil Nadu, India (S.A., P.K., P.S.).
Stroke
|April 4, 2024
概括
脑静脉血栓瘤 (CVT) 的减压神经外科手术显示出有希望的长期结果. 三分之二的严重CVT患者在手术后存活了一年,超过三分之一的患者恢复了独立性.
科学领域:
- 神经外科 神经外科
- 神经学 神经学
- 血管神经学 血管神经学
背景情况:
- 在严重的脑静脉血栓形成 (CVT) 和即将发生的大脑的情况下,建议进行减压神经外科手术,但证据有限.
- 这项研究报告了国际队列中接受解压缩神经外科手术的CVT患者的长期结果.
研究的目的:
- 评估脑静脉血栓症 (CVT) 患者减压神经外科手术的长期结果.
- 评估基线变量与CVT解压手术后患者结局之间的关联.
主要方法:
- 展望性,国际队列研究 (DECOMPRESS2) 连续CVT患者接受了解压神经外科手术.
- 在入院,出院,6个月和12个月的评估使用修改后的兰金尺度 (mRS).
- 多变量逻辑回归用于确定12个月后死亡或严重残疾 (mRS 5-6) 的预测因素.
主要成果:
- 包括来自10个国家的118名患者 (80名女性,平均年龄38岁).
- 在12个月后,39%的患者已经死亡或严重残疾 (mRS 5-6),而35.6%是独立的 (mRS 0-2).
- 昏迷和固定放大瞳孔是死亡或严重残疾的预测因素. 79%的幸存者和87%的护理人员认为手术是积极的.
结论:
- 严重CVT的减压手术导致三分之二的患者存活,三分之一以上的患者在一年内独立.
- 患者和护理人员的积极意见表明手术是值得的.
- 这些发现支持对即将发生脑的CVT患者进行解压性神经外科手术的使用.
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