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肠道微生物组会影响非小细胞肺癌免疫治疗的反应

Shengnan Ren¹, Lingxin Feng¹, Haoran Liu¹

¹Department of Oncology, the Affiliated Hospital of Qingdao University, Qingdao, China.

Thoracic cancer

|April 4, 2024

概括

肠道微生物群的多样性和像Faecalibacterium这样的特定细菌与更好的癌症免疫治疗反应有关. 便微生物群移植在延缓瘤进展和提高非小细胞肺癌治疗效率方面显示出有前途.

科学领域:

在瘤学瘤学.
微生物学微生物学
免疫学免疫学免疫学

背景情况:

癌症免疫疗法改变了治疗模式.
新出现的证据表明,肠道微生物群的组成会影响免疫治疗的疗效.
这项研究调查了肠道细菌在癌症治疗结果中的作用.

研究的目的:

分析肠道微生物群与对非小细胞肺癌 (NSCLC) 免疫检查点抑制剂 (ICI) 的反应之间的关系.
通过临床前动物模型验证肠道微生物群对免疫治疗有效性的影响.

主要方法:

在71个NSCLC患者便样本中进行了16S rRNA和GC-MS测序.
便微生物群移植 (FMT) 到小鼠与易斯肺癌模型.
在FMT后评估瘤进展和细胞标志物 (Ki-67,PD-L1).

主要成果:

更高的肠道微生物群多样性与改善的ICI反应有显著的相关性 (p < 0.05).
受访者显示菌和短链脂肪酸 (SCFA) 的增加,包括酸 (p < 0.05).
从响应者和不响应者的FMT减少了小鼠的瘤细胞增殖 (Ki-67) (p <0.05),而没有改变PD-L1表达.

结论:

肠道微生物群多样性和SCFA与NSCLC的免疫疗法疗效有关.
便微生物群移植显示有潜力延缓瘤进展并增强免疫治疗效果.
这些发现支持调节肠道微生物群的治疗潜力,以提高癌症免疫治疗结果.

关键词:

生物标志物生物标志物便微生物群的转移 (FMT)我们的肠道微生物群.免疫疗法免疫疗法非小细胞肺癌 (NSCLC) 是一种非小细胞肺癌.

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