一项人口研究,比较气管和肺腺囊性囊性癌
Yu Gu1,2,3,4, Songtao Lai1,2,3,4, Yang Wang5
1Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Cancer medicine
|April 4, 2024
概括
肺和支气管腺囊性癌 (LACC) 比气管腺囊性癌 (TACC) 更具攻击性. 局部治疗,特别是手术和放射治疗,对于改善TACC和LACC患者的存活率至关重要.
科学领域:
- 在瘤学瘤学.
- 胸部外科手术 胸部外科手术
- 癌症流行病学 癌症流行病学
背景情况:
- 胸腺囊性癌 (ACC) 是一种罕见的恶性瘤.
- 关于气管ACC (TACC) 与肺和支气管ACC (LACC) 的不同特征的了解有限.
研究的目的:
- 为了比较TACC和LACC之间的临床病理特征和生存结果.
- 确定预后因素,并为TACC和LACC开发预测模型.
主要方法:
- 来自中国癌症中心 (2005-2022) 和SEER数据库 (2000-2019) 的患者的回顾性分析.
- 计算发病率和趋势,分析临床病理特征和整体存活率 (OS).
- 构建用于OS预测的nomograms.
主要成果:
- 与TACC相比,LACC瘤较大,具有更多的淋巴结和远程转移.
- 在这两组患者中,LACC患者的中位寿命明显比TACC患者差.
- 局部治疗,特别是带或不带放射治疗的手术,改善了TACC和LACC的生存率;仅放射治疗有利于TACC,而化疗对任何一种都没有生存益处.
结论:
- 与TACC相比,LACC表现出更具侵略性的行为和更差的预后.
- 局部治疗是TACC和LACC的预后的一个关键决定因素.
- 开发出来的诺姆图可以帮助个性化的生存预测和TACC和LACC的临床决策.
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