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Updated: Jun 21, 2026

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
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在结直肠癌中识别KRAS突变相关的肠道微生物群,并构建预测机器学习模型

Zigui Huang1, Xiaoliang Huang1, Yili Huang2

  • 1Division of Colorectal & Anal Surgery, Department of Gastrointestinal Surgery, Guangxi Medical University Cancer Hospital, Nanning, China.

Microbiology spectrum
|April 4, 2024
PubMed
概括

这项研究确定了26种与结直肠癌 (CRC) 中KRAS突变相关的肠道细菌. 某些细菌,如Bifidobacterium,可能通过影响免疫细胞和生物通路来帮助预防CRC,从而有助于KRAS突变预测.

关键词:
16S rRNA 是一个16S rRNA.在KRAS突变中发生突变.结肠直肠癌是什么意思我们的肠道微生物群.机器学习是机器学习.

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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...