怀孕期间的性传播感染和不良妊娠结果:一项回顾性队列研究
Vani Govender1,2, Dhayendre Moodley1,2, Megeshinee Naidoo2
1Department of Obstetrics and Gynecology, School of Clinical Medicine, University of KwaZulu Natal, Durban, South Africa.
概括
怀孕期间无症状的性传播感染 (STIs),如Mycoplasma genitalium和Trichomonas vaginalis,与不良出生结果有关. 早期发现和治疗性传播感染对于改善青少年女孩和年轻女性的妊娠健康至关重要.
科学领域:
- 生殖健康 生殖健康
- 传染性疾病 传染性疾病
- 孕产妇和儿童的健康
背景情况:
- 在非洲,怀孕的青少年和年轻女性中,无症状性传播感染 (STIs) 的高患病率.
- 在艾滋病毒流行环境中,对性传播感染和怀孕结果之间的关联的理解有限.
研究的目的:
- 调查无症状性传播感染与南非孕妇怀孕后果之间的关联.
- 描述在不同产前访问阶段检测到的性病对出生结果的影响.
主要方法:
- 在南非克瓦祖鲁纳塔尔省对艾滋病毒阴性孕妇 (<28周妊娠期) 进行前性队列研究.
- 阴道抽样的回顾性检测,检测HSV-2,Trichomonas vaginalis,Chlamydia trachomatis和尼塞利亚淋病.
- 多变量逻辑回归分析,根据母亲的年龄和性传播疾病治疗进行调整.
主要成果:
- 在第一次产前检查时,Mycoplasma genitalium与低出生体重相关 (OR 5.22).
- 晚些时候访问的Trichomonas vaginalis与早产 (OR 2.37),低出生体重 (OR 2.56) 和不良妊娠结果 (OR 2.11) 有关.
- 在随后的访问中,HSV-2显示出与早产和不良结果相关的趋势 (OR 3.39).
结论:
- 怀孕期间无症状的Mycoplasma genitalium和Trichomonas vaginalis感染与不良出生结果有显著的相关性.
- 需要进一步研究多次产前检查和经验治疗中STI测试对怀孕结果的影响.
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