多发性硬化症患者中风的患病率和流行病学:系统性审查和元分析
Maria-Ioanna Stefanou1, Vasileios Giannopapas1, Dimitrios K Kitsos1
1Second Department of Neurology, School of Medicine, "Attikon" University Hospital, National and Kapodistrian University of Athens, Rimini 1, Chaidari, 12462, Athens, Greece.
Journal of neurology
|April 4, 2024
概括
与普通人群相比,多发性硬化症 (MS) 患者面临的中风风险明显更高,包括缺血和出血类型. 这项研究量化了MS患者中风患病率和风险因素.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 心血管研究研究心血管研究
背景情况:
- 关于多发性硬化症 (MS) 患者中风风险的流行病学数据有限.
- 了解中风风险对于管理MS并发症至关重要.
研究的目的:
- 在MS患者中确定全因中风,急性缺血性中风 (AIS) 和脑内出血 (ICH) 的患病率.
- 为了比较MS患者中风的相对风险与普通人群.
- 调查与MS中AIS和ICH风险相关的患者特征.
主要方法:
- 观察性研究的系统审查和元分析.
- 包括基于注册表和队列研究.
- 分析了13项研究中的146,381名多发性硬化患者的数据.
主要成果:
- 在MS患者中,所有原因造成的中风的综合流行率为2.7%,相对于一般人群相比,相对风险高出2.55倍.
- 综合AIS患病率为2.1%,ICH患病率为0.6%,两者都显示MS患者的相对风险增加 (AIS RR: 2.79;ICH RR: 2.31).
- 在MS患者中心血管风险因素的患病率包括失脂症 (11.5%),高血压 (18.2%) 和糖尿病 (5.4%). 年龄与AIS风险有负面关联.
结论:
- 多发性硬化症与缺血性和出血性中风的风险增加有关.
- 需要进一步的研究来证实在多发性硬化患者群体中的这些发现.
- 这项研究强调了监测MS患者中风风险的重要性.
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