在儿科急性呼吸应急综合征中,炎症和组织损伤标志物的动态
Nadir Yehya1,2, Thomas J Booth1, Gnana D Ardhanari3
1Division of Pediatric Critical Care, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia and.
The Journal of clinical investigation
|April 4, 2024
概括
儿科急性呼吸困扰综合征 (ARDS) 在幸存者和非幸存者中显示出不同的分子模式. 关键生物标志物表明过度炎症和组织损伤,与死亡率和器官功能障碍相关的特定标志物.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 肺部病理学 肺部病理学
- 分子生物学分子生物学
背景情况:
- 儿科急性呼吸困扰综合征 (ARDS) 的分子基础仍然不太清楚.
- 超炎症和组织损伤在ARDS结局中的作用尚不清楚.
研究的目的:
- 在7天内对儿科ARDS的炎症和组织损伤生物标志物进行分析.
- 将特定的生物标志物与死亡率,持久性ARDS和持久性多器官功能障碍综合征 (MODS) 联系起来.
主要方法:
- 对279名被直管的儿科ARDS患者进行前性队列研究.
- 在0日,3日和7日收集血.
- 测量了19个生物标志物 (炎症,组织损伤,DAMP) 并使用多变量混合效应模型进行分析.
主要成果:
- 与幸存者相比,未幸存者表现出较高水平的超炎性细胞因子,组织损伤标志物和DAMP.
- 在幸存者和非幸存者之间观察到不同的生物标志物轨迹.
- 特定的生物标志物,如ANG2和III型公原N终端与持久性ARDS有关,而其他生物标志物与持久性MODS有关.
结论:
- 儿童ARDS幸存者和非幸存者显示不同的生物标志物轨迹.
- 细胞因子,内皮/气囊上皮损伤和DAMP在未幸存者中升高.
- 与死亡率相关的生物标志物与与持久MODS相关的生物标志物重叠,而不是持久ARDS.
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