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肺部微生物组与肺移植接受者的术后预后之间的关联

Yuhan Wu^1,2, Linna Huang³, Min Li³

¹Department of Respiratory and Critical Care Medicine, The Second Hospital of Harbin Medical University, Harbin 150086, China.

Journal of applied microbiology

|April 4, 2024

概括

肺移植接受者的肺微生物组变化与不良结果和影响免疫力有关. 这些发现表明,肺微生物组和细胞因子是潜在的早期预后生物标志物.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
基因组学就是基因组学.

背景情况:

肺部微生物组在肺移植接受者中发生变化,影响死亡率,免疫力和基因表达.
早期移植后的肺微生物组组成及其与免疫和转录组的关系尚不清楚.

研究的目的:

在移植后的早期观察肺部微生物组的组成.
评估肺微生物群对肺细胞因子和宿主转录组的影响.
为了确定术后结果的预测值.

主要方法:

使用下一代测序进行微生物组和转录组分析的观察性研究.
对于量化膜细胞因子的Luminex测定.
斯皮尔曼的相关性分析微生物群,免疫力和基因表达之间的关系.

主要成果:

糟糕的结果与Mycoplasma/Arcobacter的增加,Gemella的减少以及IL-10,IL-1β,TNF-α的升高有关.
肺微生物组与肺免疫和差异表达基因相关.
死亡组中差异表达的基因与亡和TNF产生有关.

结论:

肺部微生物组和细胞因子显示出作为肺移植接受者的早期预后生物标志物的潜力.
肺微生物组与肺免疫和宿主基因表达变化有显著的关联.

关键词:

细胞因子细胞因子肺部微生物组是如何形成的肺部移植肺部移植这是下一代测序.预后预后预后

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