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高CASC表达预测肺癌的预后不佳:一个系统性审查与元分析
Hao Han1, Huan Huang2, An-Ping Chen1
1Department of Thoracic Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
PloS one
|April 4, 2024
概括
长非编码RNA癌症敏感性候选体 (CASC) 表达水平与肺癌预后有关. 特定的CASC类型表明良好或不良的结果,表明CASC是潜在的治疗目标.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 长非编码RNAs (lncRNAs) 越来越多地被认为是它们在癌症发育和进展中的作用.
- 包括癌症敏感性候选人 (CASC) 家族在内的lncRNAs的异常表达经常在各种癌症中观察到,包括肺癌.
- 在肺癌中CASC表达的预后意义仍然需要全面阐明.
结论:
- CASC表达水平与肺癌预后具有显著的负相关性.
- 特定的CASC亚型可以作为肺癌的独立预后生物标志物.
- 向CASC表达可能代表肺癌的潜在治疗策略.
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